Systemic Drug Discovery
Fluosphera developed a disruptive technology platform to discover the drugs most likely to succeed
Disruptive Solution: Illuminating the effect of drugs in vitro
Leveraging decades of progress in cell biology and genetics, FluoSphera uses the precision of fluorescent light to measure multiple biological processes in multiple human cell types in co-culture - simultaneously.
Liquid Microphysiological Systems
Flexible cell systems recapitulating the complexity of the human body.
Multiplexing
Unique combination of color-coded capsules with fluorescent probes to measure cellular activities.
Mass Imaging
Extensive exploration of biological effects in advanced tissue model using automated Microscopy.
How our system works:
Tissues A and B are encapsulated into permeable color-code capsules for the identification of the tissue types.
Biological activities (effects 1 and 2) can be detected with fluorescent reagents and/or fluorescent reporter genes. A sophisticated microscopy analysis is performed with an imaging software.
Technology Toolbox
The capsule physically separates the different tissues from each other and allows them to exchange soluble factors, like in human body.
The capsule controls the size of the spheroid below 300 µm, compatible with oxygen and nutrients diffusion, like in perfused tissues.
Within a few days after encapsulation, cells form spheroids, well-known to recapitulate the spatial organization of tissues.
A capsule color is assigned to each tissue type for their recognition even in a complex multi-culture, without labelling cells.
Acquisition and analysis of fluorescent patterns with a strong multiplexing capacity with the technology of High-Content Screening (HCS).
Our technology comprises a set of tools that can be individually adjusted to generate tailor-made in vitro models.
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