Fluosphera has unique tissue engineering expertise to predict the complex effects of drugs.
Leveraging decades of progress in cell biology and genetics, FluoSphera uses the precision of fluorescent light to measure multiple biological processes in multiple human cell types in co-culture - simultaneously.
Flexible cell systems recapitulating the complexity of the human body.
Unique combination of color-coded capsules with fluorescent probes to measure cellular activities.
Extensive exploration of biological effects in advanced tissue model using automated Microscopy.
Tissues A and B are encapsulated into permeable color-code capsules for the identification of the tissue types.
Biological activities (effects 1 and 2) can be detected with fluorescent reagents and/or fluorescent reporter genes. A sophisticated microscopy analysis is performed with an imaging software.
The capsule physically separates the different tissues from each other and allows them to exchange soluble factors, like in human body.
The capsule controls the size of the spheroid below 300 µm, compatible with oxygen and nutrients diffusion, like in perfused tissues.
Within a few days after encapsulation, cells form spheroids, well-known to recapitulate the spatial organization of tissues.
A capsule color is assigned to each tissue type for their recognition even in a complex multi-culture, without labelling cells.
Acquisition and analysis of fluorescent patterns with a strong multiplexing capacity with the technology of High-Content Screening (HCS).
Our technology comprises a set of tools that can be individually adjusted to generate tailor-made in vitro models.
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